Chromosomal Microarray Analysis for Miscarriage

According to statistical data, up to sixty percent of repeated miscarriage is of hereditary factor. By using miscarriage tissue microarray analysis, it is possible to find the real cause of miscarriage and reduce the stress on pregnant women.

Is that important to analyze the miscarriage tissue?

Clinically, themiscarriage rate is as high as 15-25%. The incidence of two consecutive miscarriages is less than 5%, and up to 1% experience three consecutive miscarriages (i.e. repeated miscarriage).

By performing chromosomal analysis on the miscarriage tissue, its cause can be clarified to help physicians select the appropriate auxiliary treatment, which is significant for families experienced natural or repeated abortions.

Possible reason of repeated miscarriage

Most natural miscarriages are caused by poor embryonic quality. From Eugenic point of view, natural miscarriage is not a real bad thing. The most important thing is to find the cause of miscarriage to give birth to a healthy baby in the next gestation.

Possible reason and percentage

Explore via karyotyping and microarray analysis

  • Whether miscarriage is caused by fetal or parental chromosomal abnormality
  • Avoid unnecessary tests and incorrect treatment to reduce miscarriage and improve pregnancy rate
  • Explain miscarriage with science to reduce unwanted psychological burden on patients
  • Reduce treatment cost
  • Better accuracy by discovering the mutations not detectable with conventional technology

According to ACOG recommendation, fetal chromosome and gene tests should be conducted for stillborn of >20 weeks Chromosome karyotyping discovers about 50% abnormalities from the tissue of miscarriage tissue at <12 weeks. An additional 15~20% can be achieved with the use of gene microarrays. Conventional chromosome karyotyping requires cell culturing with nearly 20% failure rate (i.e. without result), so it is replaced by gene microarrays.

Indications

  • Women with the history of two or more miscarriages
  • Women of geriatric pregnancy with the history of one miscarriage
  • None of the above, but wants to know the cause

Test procedure

1

Obtain written informed consent after thorough medical consultation

2

Collect sample from the miscarriage tissue

3

Samples submitted to laboratory for testing

4

Chromosomal culturing and microarray analysis

5

Report provided by the physician

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